From DNA binding to transcriptional activation: Is the TALE complete?

Published in: The Journal of cell biology (2017)

How transcription factors (TFs) control enhancer and promoter functions to effect changes in gene expression is an important question. In this issue, Hau et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201701154) show that the TALE TF MEIS recruits the histone modifier PARP1/ARTD1 at promoters to decompact chromatin and activate transcription.

Keyphrases

transcription factor
dna binding
gene expression
dna methylation
dna damage
single cell
cell therapy
dna repair
genome wide identification
genome wide
stem cells
mesenchymal stem cells