Real-Time Biosensor Platform Based on Novel Sandwich Graphdiyne for Ultrasensitive Detection of Tumor Marker.
Jing XuYinbing LiuKe-Jing HuangYang-Yang HouXiaoxuan SunJiaqiang LiPublished in: Analytical chemistry (2022)
Realization of a highly sensitive analysis and sensing platform is important for early-stage tumor diagnosis. In this work, a self-powered biosensor with a novel sandwich graphdiyne (SGDY) combined with an aptamer-specific recognition function was developed to sensitively and accurately detect tumor markers. Results indicated that the detection limits of microRNA (miRNA)-21 and miRNA-141 were 0.15 and 0.30 fM (S/N = 3) in the linear range of 0.05-10000 and 1-10000 fM, respectively. The newly designed platform has great promise for early-stage tumor diagnosis.
Keyphrases
- early stage
- label free
- gold nanoparticles
- high throughput
- sensitive detection
- quantum dots
- squamous cell carcinoma
- loop mediated isothermal amplification
- machine learning
- sentinel lymph node
- radiation therapy
- deep learning
- mass spectrometry
- neoadjuvant chemotherapy
- data analysis
- living cells
- locally advanced
- solid phase extraction