Pharmacokinetic and toxicodynamic evaluation of 5-fluorouracil administration after major hepatectomy in a rat model.

Kazuhiro TadaYukio IwashitaKen ShiraiwaHiroki UchidaYusuke OshimaYuhki SatoHiroaki NakanumaTeijiro HirashitaTakashi MasudaYuichi EndoYu TakeuchiMasayuki OhtaHiroki ItohMasafumi Inomata

Published in: Cancer chemotherapy and pharmacology (2019)

Reduction of the total liver DPD following major hepatectomy caused increased plasma 5-FU levels and 5-FU-associated toxicity.

Keyphrases

liver metastases
oxidative stress