A unified strategy for the synthesis of aldohexoses by boronate assisted assembly of CH 2 X 2 derived C 1 -building blocks.

A synthetic strategy for all aldohexoses with individually addressable protecting groups from dihalomethane C 1 -units is reported. The underlying synthesis of C 6 -sugar alcohols relies on three consecutive Matteson sequences, vinylation and bishydroxylation. Erythro and threo isomers have been realized for every glycol motif by strategic variation of the sequence.