Mechanistic modelling of enzyme-restoration effects of new recombinant liver-targeted proteins in acute intermittent porphyria.

Diego Vera-YuncaKarol M CórdobaZinnia P Parra-GuillenDaniel JericóAntonio FontanellasIñaki F Trocóniz

Published in: British journal of pharmacology (2022)

The model developed had excellent performance over a range of doses and formulation type. This mechanistic model warrants use beyond ApoAI-conjugates and represents a useful tool towards more efficient drug treatments of other enzymopenias as well as for acute intermittent porphyria.

Keyphrases

liver failure
respiratory failure
drug induced
high intensity
aortic dissection
cancer therapy
drug delivery
hepatitis b virus
emergency department
electronic health record