H. pylori-induced NF-κB-PIEZO1-YAP1-CTGF axis drives gastric cancer progression and cancer-associated fibroblast-mediated tumour microenvironment remodelling.
Bonan ChenXiaoli LiuPeiyao YuFuda XieJohnny S H KwanWai Nok ChanCanbin FangJinglin ZhangAlvin H K CheungChit ChowGloria W M LeungKam Tong LeungShihua ShiBin ZhangShouyu WangDazhi XuKaili FuChi Chun WongWilliam K K WuMichael W Y ChanPatrick M K TangChi Man TsangKwok Wai LoGary M K TseShuang YuKa Fai ToWei KangPublished in: Clinical and translational medicine (2023)
This study elucidates a novel driving PIEZO1-YAP1-CTGF force, which opens a novel therapeutic avenue to block the transformation from precancerous lesions to GC. H. pylori-NF-κB activates the PIEZO1-YAP1-CTGF axis to remodel the GC microenvironment by promoting CAF infiltration. Targeting PIEZO1-YAP1-CTGF plus chemotherapy might serve as a potential therapeutic option to block GC progression and peritoneal metastasis.