Alzheimer's disease and cerebrovascular pathology alter brain endothelial inward rectifier potassium (KIR 2.1) channels.

María Lacalle-AuriolesLianne J TrigianiMiled BourourouClotilde LecruxEdith Hamel

Published in: British journal of pharmacology (2021)

Therapies targeting both oxidative stress and inflammation are necessary for full recovery of KIR 2.1 channel function in cerebrovascular pathology caused by AD and CVD.

Keyphrases

oxidative stress
dna damage
ischemia reperfusion injury
diabetic rats
endothelial cells
white matter
cognitive decline
induced apoptosis
cancer therapy
signaling pathway
mild cognitive impairment
heat shock protein