Detectable plasma severe acute respiratory syndrome coronavirus 2 spike antigen is associated with poor antibody response following third messenger RNA vaccination in kidney transplant recipients.
Andrew H KarabaZoe SwankSarah HussainMargaret ChahoudChristine M DurandDorry L SegevMark A RobienPeter S HeegerChristian P LarsenAaron A R TobianDavid R WaltWilliam A WerbelPublished in: Transplant infectious disease : an official journal of the Transplantation Society (2024)
Inadequate plasma sAg does not likely drive poor antibody responses in KTRs, rather sAg detection implies insufficient immune response to rapidly clear vaccine antigen from blood. Other downstream mechanisms such as sAg trafficking and presentation should be explored.