Cannabinoid modulation of opioid analgesia and subjective drug effects in healthy humans.
Shanna BabalonisMichelle R LofwallPaul A SloanPaul A NuzzoLaura C FanucchiSharon L WalshPublished in: Psychopharmacology (2019)
This study indicates that dronabinol did not enhance the analgesic effects of oxycodone and increased abuse- and impairment-related subjective effects. These data suggest that dronabinol may not be an effective or appropriate opioid adjuvant; it could potentially increase opioid dose requirements, while increasing psychoactive opioid effects.