P53 Activation Promotes Maturational Characteristics of Pluripotent Stem Cell-Derived Cardiomyocytes in 3-Dimensional Suspension Culture Via FOXO-FOXM1 Regulation.
Nivedhitha VelayuthamJessica C GarbernHannah L T ElwellZhu ZhuoLaura RülandFarid Elcure AlvarezSara FrontiniYago Rodriguez CarrerasMarie EichholtzElisabeth Ricci-BlairJeanna Y ShawAldric H BouffardMorgan SokolEstela Mancheño JuncosaSeth RhoadesDaphne van den BergAlexander KreymermanJunya AoyamaJens HöfflinHerb RyanShannan Ho SuiRichard T LeePublished in: Journal of the American Heart Association (2024)
We show that p53 activation promotes FOXO and suppresses FOXM1 during 3-dimensional hiPSC-CM maturation. These results expand our understanding of hiPSC-CM maturational mechanisms in a clinically-relevant 3-dimensional culture system.