Immunocytochemistry for ARID1A as a potential biomarker in urine cytology of bladder cancer.

Sarah G DugasDavid C MüllerClémentine Le MagnenJoel Federer-GsponerHans-Helge SeifertChristian RuizSpasenija Savic PrinceTatjana VlajnicTobias ZellwegerKirsten D MertzJack V W BaconAlexander W WyattCyrill A RentschLukas Bubendorf

Published in: Cancer cytopathology (2019)

The authors have suggest ARID1A ICC as a promising surrogate marker for ARID1A mutational status in patients with urothelial carcinoma. Pitfalls in ICC scoring include benign umbrella cells that often are negative for ARID1A. Further prospective studies are needed to determine the clinical relevance of ARID1A ICC in urinary cytology.

Keyphrases

high grade
fine needle aspiration
induced apoptosis
ultrasound guided
systematic review
cell cycle arrest
cell proliferation
cell death
pi k akt