INCREASED PLATELET MITOCHONDRIAL FUNCTION CORRELATES WITH CLOT STRENGTH IN A RODENT FRACTURE MODEL.

James Blake LittlejohnEmily Evans GrennKristen T CarterAna C PaleiFrank T SpradleyJonathan P HoslerNgoc H HoangKristin S EdwardsMatthew E Kutcher

Published in: The journal of trauma and acute care surgery (2023)

Platelet mitochondrial basal respiration is increased after injury and correlates with clot strength in this rodent hindlimb fracture model. Several mitochondrial-targeted therapeutics exist in common use that are underexplored but hold promise as potential antithrombotic adjuncts that can be sensitively evaluated in this preclinical model.

Keyphrases

oxidative stress
atrial fibrillation
drug delivery
machine learning
cell therapy
big data
mesenchymal stem cells
climate change