Risk, Timing, and Predictors of Disease Flare After Discontinuation of Anti-Tumor Necrosis Factor Therapy in Children With Polyarticular Forms of Juvenile Idiopathic Arthritis With Clinically Inactive Disease.
Daniel J LovellAnne L JohnsonBin HuangBeth S GottliebPaula W MorrisYukiko KimuraKaren OnelSuzanne C LiAlexei A GromJanalee TaylorHermine I BrunnerJennifer L HugginsJames J NoctonKathleen A HainesBarbara S EdelheitMichael ShishovLawrence K JungCalvin B WilliamsMelissa S TesherDenise M CostanzoLawrence S ZemelJason A DareMurray H PassoKaleo C EdeJudyann C OlsonElaine A CassidyThomas A GriffinLinda Wagner-WeinerJennifer E WeissLarry B VoglerKelly A Rouster-StevensTimothy BeukelmanRandy Q CronDaniel KietzKenneth SchiklerKara M SchmidtJay MehtaDawn M WaheziTracy V TingJames W VerbskyB Anne EberhardSteven SpaldingChen ChenEdward H GianniniPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2018)
Over one-third of patients with polyarticular JIA with sustained clinically inactive disease will experience a flare by 8 months after discontinuation of anti-TNF therapy. Several predictors of lower likelihood of flare were identified.