The dynamin-related protein Dyn2 is essential for both apicoplast and mitochondrial fission in Plasmodium falciparum .

Alexander A MoranoWei XuNeeta ShadijaJeffrey D Dvorin Hangjun Ke

Published in: bioRxiv : the preprint server for biology (2024)

PfDyn2 is essential for schizont-stage development.PfDyn2 mediates both apicoplast and mitochondrial fission.Deficiency of PfDyn2 leads to organellar fission failures and blockage of basal complex contraction.Addition of apicoplast-derived metabolite IPP does not rescue the growth defects.

Keyphrases

plasmodium falciparum
oxidative stress
smooth muscle
replacement therapy