A lipase-responsive antifungal nanoplatform for synergistic photodynamic/photothermal/pharmaco-therapy of azole-resistant Candida albicans infections.

Dongliang YangXinyi LvLei XueNan YangYanling HuLixing WengNina FuLian-Hui Wang Xiaochen Dong

Published in: Chemical communications (Cambridge, England) (2019)

A lipase-triggered drug release nanoplatform (PGL-DPP-FLU NPs) for multi-modal antifungal therapy is developed. The lipases secreted by C. albicans can accelerate FLU release. The ROS and heat produced by PGL-DPP-FLU NPs make C. albicans more vulnerable to FLU, thereby PGL-DPP-FLU NPs exhibit high performance for combating azole-resistant C. albicans biofilms and wound infection.

Keyphrases

candida albicans
drug release
cancer therapy
drug delivery
biofilm formation
photodynamic therapy
stem cells
staphylococcus aureus
reactive oxygen species
oxidative stress
pseudomonas aeruginosa
escherichia coli
cell therapy