A novel algorithm for the virtual screening of extensive small molecule libraries against ERCC1/XPF protein-protein interaction for the identification of resistance-bypassing potential anticancer molecules.

Salma Ghazy Lalehan Oktay Serdar Durdagi

Published in: Turkish journal of biology = Turk biyoloji dergisi (2024)

The algorithm implemented in this study expands our comprehension of chemotherapeutic resistance and how to overcome it through identifying ERCC1/XPF inhibitors with the aim of enhancing chemotherapeutic impact giving hope for ameliorated cancer treatment outcomes.

Keyphrases

small molecule
protein protein
machine learning
dna repair
deep learning
papillary thyroid
dna damage
squamous cell carcinoma
risk assessment