Quantitative evaluation of the relationship between COMP promoter methylation and the susceptibility and curve progression of adolescent idiopathic scoliosis.

Sai-Hu MaoBang-Ping QianBenlong ShiZe-Zhang ZhuYong Qiu

Published in: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society (2017)

AIS patients had significantly high COMP promoter methylation and low gene expression. Positive and high COMP promoter methylation was correlated with young age and high Cobb angle of main curve. Therefore, COMP gene promoter methylation may provide significant prognostic information in predicting the susceptibility and curve progression of AIS.

Keyphrases

dna methylation
gene expression
genome wide
transcription factor
copy number
end stage renal disease
ejection fraction
high resolution
newly diagnosed
health information
mass spectrometry
middle aged
patient reported