Phytochemical Investigation of Tradescantia Albiflora and Anti-Inflammatory Butenolide Derivatives.
Ping-Chen TuHan-Chun TsengYu-Chia LiangGuan-Jhong HuangTe-Ling LuTzong-Fu KuoYueh-Hsiung KuoPublished in: Molecules (Basel, Switzerland) (2019)
Phytochemical investigation of the whole plant of Tradescantia albiflora Kunth led to the isolation and characterization of a butanolide, rosmarinosin B (1), that was isolated from natural sources for the first time, a new butenolide, 5-O-acetyl bracteanolide A (2), and a new apocarotenoid, 2β-hydroxyisololiolide (11), together with 25 known compounds (compounds 3-10 and 12-28). The structures of the new compounds were elucidated by analysis of their spectroscopic data, including MS, 1D, and 2D NMR experiments, and comparison with literature data of known compounds. Furthermore, four butenolides 4a-4d were synthesized as novel derivatives of bracteanolide A. The isolates and the synthesized derivatives were evaluated for their preliminary anti-inflammatory activity against lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production in RAW 264.7 cells. Among them, the synthesized butenolide derivative n-butyl bracteanolide A (4d) showed enhanced NO inhibitory activity compared to the original compound, with an IC50 value of 4.32 ± 0.09 μg/mL.
Keyphrases
- anti inflammatory
- nitric oxide
- high resolution
- inflammatory response
- electronic health record
- induced apoptosis
- multiple sclerosis
- mass spectrometry
- magnetic resonance
- molecular docking
- ms ms
- structure activity relationship
- toll like receptor
- immune response
- oxidative stress
- drinking water
- cell death
- nitric oxide synthase
- deep learning
- pi k akt