Serum Inflammatory and Oxidative Stress Markers in Patients with Vitiligo.
Asma KassabYassine KhalijYosra AyedNajla Dar-OdehAmal A KokandiMeriam DenguezliMonia YoussefPublished in: Journal of clinical medicine (2023)
In vitiligo, oxidative damage induces an increase in pro-inflammatory IL-15, which in turn promotes IFN-γ-inducible chemokines such as CXCL9 and CXCL10. Further, there seems to be a link between the VASI score and IL-15 levels. These data imply that inhibiting IL-15 could be a promising method for developing a potentially targeted treatment that suppresses the early interplay between oxidant stress and IL-15 keratinocyte production, as well as between resident and recirculating memory T cells.