Bile acids increase steroidogenesis in cholemic mice and induce cortisol secretion in adrenocortical H295R cells via S1PR2, ERK and SF-1.

Lei LiuKatrin PanzittSilvia RacedoMartin WagnerWolfgang PlatzerAlex ZaufelVerena Theiler-SchwetzBarbara Obermayer-PietschHelmut MüllerGerald HöflerAkos HeinemannGernot Zollner Peter Fickert

Published in: Liver international : official journal of the International Association for the Study of the Liver (2019)

Our findings indicate that supraphysiological bile acid levels as observed in cholestasis stimulate steroidogenesis via an S1PR2-ERK-SF-1 signalling pathway.

Keyphrases

signaling pathway
induced apoptosis
pi k akt
cell cycle arrest
cell proliferation
high fat diet induced
endoplasmic reticulum stress
type diabetes
oxidative stress
drug induced
metabolic syndrome
insulin resistance
skeletal muscle
wild type