Multifunctional Lipophobic Polymer Dots from Cyclodextrin: Antimicrobial/Anticancer Laborers and Silver Ions Chemo-Sensor.
Albandary AlmahriAmeena M Al-BonayanRoba M S AttarAlaa KarkashanBasma AbbasSalhah D Al-QahtaniNashwa M El-MetwalyPublished in: ACS omega (2023)
β-Cyclodextrin (CD) is currently exploited for the implantation of lipophobic polymer dots (PDs) for antimicrobial and anticancer laborers. Moreover, the PDs were investigated to act as a chemo-sensor for metal detection. The data revealed that under basic conditions, photoluminescent PDs (5.1 nm) were successively clustered with a controllable size at 190 °C, whereas under acidic conditions, smaller-sized non-photoluminescent carbon nanoparticles (2.9 nm) were obtained. The fluorescence intensity of synthesized PDs under basic conditions was affected by pH, and such an intensity was significantly higher compared to that prepared under acidic conditions. The PDs were exploited as florescent detectors in estimation of Ag + ions in aquatic streams. Treatment of Ag + ion colloids with PDs resulted in fluorescence quenching attributing to the production of AgNPs that approved by spectral studies. The cell viability percent was estimated for Escherichia coli , Staphylococcus aureus, and Candida albicans after incubation with PDs implanted under basic conditions for 24 h. The cell mortality percent was estimated for breast cancer (MCF-7) after incubation with different concentrations of PDs that were implanted under acidic versus basic conditions to show that treatment of the tested cells with 1000 μg/mL PDs prepared under basic (IC50 232.5 μg/mL) and acidic (IC 50 88.6 μg/mL) conditions resulted in cell mortality percentages of 70 and 90%, respectively.
Keyphrases
- staphylococcus aureus
- candida albicans
- ionic liquid
- escherichia coli
- photodynamic therapy
- single cell
- biofilm formation
- quantum dots
- risk assessment
- cardiovascular events
- energy transfer
- cardiovascular disease
- gold nanoparticles
- cancer therapy
- cell therapy
- single molecule
- oxidative stress
- risk factors
- squamous cell carcinoma
- pseudomonas aeruginosa
- combination therapy
- breast cancer cells
- fluorescent probe
- computed tomography
- methicillin resistant staphylococcus aureus
- replacement therapy
- capillary electrophoresis
- cell cycle arrest
- drug delivery
- magnetic resonance
- cell death
- light emitting
- contrast enhanced
- high speed
- atomic force microscopy
- simultaneous determination
- locally advanced