Do Obesity-Related Traits Affect Prostate Cancer Risk through Serum Testosterone? A Mendelian Randomization Study.

Chi YuanZhongyu JianShijian FengMenghua WangLiyuan XiangHong LiXi JinKun-Jie Wang

Published in: Cancers (2023)

Our study provided genetic evidence that serum BT can mediate the effect of BMI on the risk of PCa, indicating the possible mechanism by which obesity reduces PCa risk.

Keyphrases

prostate cancer
metabolic syndrome
insulin resistance
weight loss
type diabetes
weight gain
genome wide
body mass index
adipose tissue
high fat diet induced
gene expression
replacement therapy
smoking cessation