Differential Effect of Polymorphisms on Body Mass Index Across the Life Course of Japanese: The Japan Multi-Institutional Collaborative Cohort Study.
Madoka IwaseKeitaro MatsuoMasahiro NakatochiIsao OzeHidemi ItoYuriko KoyanagiTomotaka UgaiYumiko KasugaiAsahi HishidaKenji TakeuchiRieko OkadaYoko KuboChisato ShimanoeKeitaro TanakaHiroaki IkezakiMasayuki MurataToshiro TakezakiDaisaku NishimotoNagato KuriyamaEtsuko OzakiSadao SuzukiMiki WatanabeHaruo MikamiYohko NakamuraHirokazu UemuraSakurako Katsuura-KamanoKiyonori KurikiYoshikuni KitaNaoyuki TakashimaMasato NaginoYukihide MomozawaMichiaki KuboKenji WakaiPublished in: Journal of epidemiology (2020)
Previously reported BMI-associated loci discovered in Europeans were also identified in the Japanese population. Additionally, our results suggest that the effects of each loci on BMI may vary across the life course and that this variation may be caused by the differential effects of individual genes on BMI via different pathways.