Tumorigenic mechanisms of estrogen and Helicobacter pylori cytotoxin-associated gene A in estrogen receptor α-positive diffuse-type gastric adenocarcinoma.

Seungkyung KangMiree ParkJung Yeon ChoSu Jin AhnChanghwan YoonSang Gyun KimSoo-Jeong Cho

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2022)

These findings may explain the rapid DGC progression in young women with physiologically high levels of estrogen and suggest that fulvestrant with ovarian function suppression could serve as a tumor-suppressive agent in premenopausal patients with DGC.

Keyphrases

estrogen receptor
helicobacter pylori
helicobacter pylori infection
squamous cell carcinoma
postmenopausal women
copy number
genome wide
low grade
middle aged
locally advanced
high grade
radiation therapy
rectal cancer
sensitive detection