Enriched environment ameliorates adult hippocampal neurogenesis deficits in Tcf4 haploinsufficient mice.
Katharina BraunBenjamin M HäberleMarie-Theres WittmannDieter Chichung LiePublished in: BMC neuroscience (2020)
The present findings indicate that haploinsufficiency for the intellectual disability- and PTHS-linked transcription factor TCF4 not only affects embryonic neurodevelopment but impedes neurogenesis in the hippocampus of adult mice. These findings suggest that TCF4 haploinsufficiency may have a negative impact on hippocampal function throughout adulthood by impeding hippocampal neurogenesis.
Keyphrases
- cerebral ischemia
- intellectual disability
- subarachnoid hemorrhage
- blood brain barrier
- brain injury
- transcription factor
- autism spectrum disorder
- high fat diet induced
- neural stem cells
- traumatic brain injury
- depressive symptoms
- temporal lobe epilepsy
- type diabetes
- mouse model
- dna binding
- adipose tissue
- wild type
- skeletal muscle
- metabolic syndrome
- insulin resistance