FRK inhibits glioblastoma progression via phosphorylating YAP and inducing its ubiquitylation and degradation by Siah1.

Yan Wang Kai Wang Jiale Fu Yu Zhang Yufei Mao Xu Wang Xiang WangRutong YuXiu-Ping Zhou

Published in: Neuro-oncology (2022)

We identify a novel mechanism by which FRK orchestrates tumor-suppression effect through phosphorylating YAP and inducing its ubiquitination by Siah1. FRK-Siah1-YAP signaling axis may serve as a potential therapeutic target for GBM treatment.

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