Vitamin D3 modulates the innate immune response through regulation of the hCAP-18/LL-37 gene expression and cytokine production.

Daniel SvenssonDaniel NebelBengt-Olof Nilsson

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2015)

In the present review, we discuss 1,25D3-induced down-regulation of cytokine/chemokine production and stimulation of hCAP-18/LL-37 gene expression which represent two very important pathways for 1,25D3-evoked regulation of the innate immune response.

Keyphrases

gene expression
immune response
innate immune
dna methylation
dendritic cells
toll like receptor
high glucose
drug induced