Genome-Wide Association Meta-Analysis of Single-Nucleotide Polymorphisms and Symptomatic Venous Thromboembolism during Therapy for Acute Lymphoblastic Leukemia and Lymphoma in Caucasian Children.
Marion K MateosMorten TulstrupMichael Cj QuinnRuta TuckuvieneGlenn M MarshallRamneek GuptaChelsea MayohBenjamin Ole WolthersPasquale M BarbaroEllen RuudRosemary SuttonPasi HuttunenTamas ReveszSonata S TrakymieneDraga BarbaricUlf TedgårdJodie E GilesFrank AlvaroOlafur G JonssonFrançoise MechinaudKadri SaksDaniel R CatchpooleRishi Sury KotechaLuciano Dalla-PozzaGeorgia Chenevix-TrenchToby N TrahairStuart MacGregorKjeld SchmiegelowPublished in: Cancers (2020)
This represents the largest GWAS meta-analysis conducted to date associating SNPs to VTE in children and adolescents treated on childhood ALL protocols. Validation of these findings is needed and may then lead to patient stratification for VTE preventive interventions. As VTE hemostasis involves multiple pathways, a more powerful GWAS is needed to detect combination of variants associated with VTE.