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Fecal Dysbiosis and Inflammation in Intestinal-Specific Cftr Knockout Mice on Regimens Preventing Intestinal Obstruction.

Sarah M YoungRowena A WoodeEstela WilliamsAaron C EricssonLane L Clarke
Published in: bioRxiv : the preprint server for biology (2023)
Chronic intestinal inflammation is a manifestation of cystic fibrosis (CF), a disease caused by loss of the anion channel CFTR that is expressed in many tissues. This study shows that intestinal epithelial cell-specific loss of CFTR (iCftr KO) in mice is sufficient to induce intestinal dysbiosis and inflammation. Studies were performed on mice consuming either dietary regimen (PEG laxative or liquid diet) routinely used to prevent obstruction in CF mice.
Keyphrases
  • cystic fibrosis
  • pseudomonas aeruginosa
  • oxidative stress
  • lung function
  • high fat diet induced
  • ionic liquid
  • drug delivery
  • gene expression
  • weight loss
  • type diabetes
  • insulin resistance
  • adipose tissue
  • skeletal muscle