Necrosis Factor-α (TNF-α) and the Presence of Macrophage M2 and T Regulatory Cells in Nasopharyngeal Carcinoma.
Iffah MardhiyahYustina Nuke ArdiyanSiti Hamidatul AliyahEnda Cindylosa SitepuCamelia HerdiniChetana Prakash DeshmukhFatin AsfarinaSumartiningsih SumartiningsihJajah FachirohDewi Kartikawati ParamitaPublished in: Asian Pacific journal of cancer prevention : APJCP (2021)
TNFα has a positive correlation with M2 and Treg distribution,but mostly through a different mechanism other than EBER-TLR3 interaction. Possibly, other pro-inflammatory and anti-inflammatory cytokines are involved in the formation of the NPC microenvironment, especially related to the presence of M2 and Treg, which provide immunosuppressive effects in NPC tumors. <br />.