Reversal of pancreatic desmoplasia by a tumour stroma-targeted nitric oxide nanogel overcomes TRAIL resistance in pancreatic tumours.

Hsi-Chien HuangYun-Chieh SungChung-Pin LiDehui WanPo-Han ChaoYu-Ting TsengBo-Wen LiaoHui-Teng ChengFu-Fei HsuChieh-Cheng HuangYi-Ting ChenYu-Hui LiaoHsin Tzu HsiehYu-Chuan ShihI-Ju LiuHan-Chung WuTsai-Te LuJane WangYunching Chen

Published in: Gut (2021)

The co-delivery of TRAIL and NO by a stroma-targeted nanogel that remodels the fibrotic tumour microenvironment and suppresses tumour growth has the potential to be translated into a safe and promising treatment for PDAC.

Keyphrases

nitric oxide
cancer therapy
stem cells
signaling pathway
nitric oxide synthase
hydrogen peroxide
drug delivery
combination therapy