Safety and efficacy of tolcapone in Parkinson's disease: systematic review.

Carlo Alberto ArtusiLidia SarroGabriele ImbalzanoMargherita FabbriLeonardo Lopiano

Published in: European journal of clinical pharmacology (2021)

Literature data showed the absence of relevant safety concerns of tolcapone when strict adherence to hepatic function monitoring is respected. Given its high efficacy on motor fluctuations, tolcapone is probably an underutilized tool in the therapeutic PD armamentarium.

Keyphrases

systematic review
meta analyses
electronic health record
metabolic syndrome
machine learning
artificial intelligence