Synthesis of Lipophilic Core-Shell Fe3O4@SiO2@Au Nanoparticles and Polymeric Entrapment into Nanomicelles: A Novel Nanosystem for in Vivo Active Targeting and Magnetic Resonance-Photoacoustic Dual Imaging.
Ilaria MonacoFrancesca ArenaStefania BiffiErica LocatelliBarbara BortotFrancesca La CavaGiada Maria MariniGiovanni Maria SeveriniEnzo TerrenoMauro Comes FranchiniPublished in: Bioconjugate chemistry (2017)
In this work, iron/silica/gold core-shell nanoparticles (Fe3O4@SiO2@Au NPs) characterized by magnetic and optical properties have been synthesized to obtain a promising theranostic platform. To improve their biocompatibility, the obtained multilayer nanoparticles have been entrapped in polymeric micelles, decorated with folic acid moieties, and tested in vivo for photoacoustic and magnetic resonance imaging detection of ovarian cancer.
Keyphrases
- cancer therapy
- drug delivery
- magnetic resonance
- magnetic resonance imaging
- fluorescence imaging
- drug release
- reduced graphene oxide
- sensitive detection
- high resolution
- photodynamic therapy
- contrast enhanced
- computed tomography
- loop mediated isothermal amplification
- gold nanoparticles
- molecularly imprinted
- label free
- magnetic nanoparticles
- oxide nanoparticles
- real time pcr
- single cell
- tissue engineering
- iron deficiency