TRIM18 is a critical regulator of viral myocarditis and organ inflammation.
Mingli FangAo ZhangYong DuWenting LuJunying WangLaurie J MinzeTimothy C CoxXian Chang LiJunji XingZhiqiang ZhangPublished in: Journal of biomedical science (2022)
Our results indicate that TRIM18 serves as a negative regulator of viral myocarditis, lung inflammation and brain damage by downregulating innate immune activation induced by both RNA and DNA viruses. Our data reveal that TRIM18 is a critical regulator of innate immunity in viral induced diseases, thereby identifying a potential therapeutic target for treatment.
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