Role of Beta Cell Function and Insulin Resistance in the Development of Gestational Diabetes Mellitus.
Jonas EllerbrockBenthe SpaandermanJoris van DrongelenEva MulderVeronica Lopes van BalenVeronique SchifferLaura JorissenRobert-Jan AlersJeanine LeenenChahinda Ghossein-DohaMarc SpaandermanPublished in: Nutrients (2022)
Both high insulin resistance and beta cell dysfunction increase the risk of GDM. As increased insulin resistance, rather than beta cell function, is related to an insufficient response to a low carbohydrate diet, we speculate that insulin sensitizers rather than insulin therapy may be the most targeted therapeutic modality in diet-insensitive GDM.
Keyphrases
- insulin resistance
- type diabetes
- glycemic control
- adipose tissue
- weight loss
- physical activity
- high fat diet
- polycystic ovary syndrome
- metabolic syndrome
- skeletal muscle
- single cell
- cell therapy
- high fat diet induced
- oxidative stress
- cancer therapy
- mesenchymal stem cells
- drug delivery
- pregnancy outcomes
- replacement therapy