Synergistic Lethality Effects of Apatinib and Homoharringtonine in Acute Myeloid Leukemia.

Yuan-Fei ShiDandan XuYi XuHuafei ShenYan ZhangXiujin YeJie JinDawei Cui Wanzhuo Xie

Published in: Journal of oncology (2022)

Our preclinical data demonstrate that Apatinib combined with HHT exerts a better antileukemia effect than Apatinib alone by inhibiting the VEGFR-2 signaling pathway, suggesting the potential role of Apatinib and HHT in the treatment of AML. This study provides clinicians with innovative combination therapies and new therapeutic targets for the treatment of AML.

Keyphrases

signaling pathway
acute myeloid leukemia
palliative care
stem cells
machine learning
mesenchymal stem cells
oxidative stress
electronic health record
drug delivery
induced apoptosis
deep learning