Validation of Constant Work Rate Cycling Endurance Time for Use in Chronic Obstructive Pulmonary Disease Clinical Trials.

Richard CasaburiDebora MerrillNancy Kline LeidyNicholas LocantoreThomas DolmageJudith Garcia-AymerichRoger GoldsteinGale HardingFrançois MaltaisDenis O'DonnellJanos PorszaszLuis Puente MaestuStephen RennardHarry B RossiterFrank SciurbaMartijn A SpruitRuth Tal-SingerKay TetzlaffA J Alex van 't HulRen YuAlan Hamilton

Published in: Annals of the American Thoracic Society (2023)

Constant work rate cycling endurance time is a valid exercise endurance measure in COPD, suitable for contributing to evaluation of treatment benefit supporting regulatory decision-making and evidence-based therapeutic recommendations.

Keyphrases

high intensity
resistance training
clinical trial
decision making
skeletal muscle
chronic obstructive pulmonary disease
transcription factor
clinical practice
physical activity
phase ii
combination therapy
study protocol