Metabolic syndrome is associated with higher rate of gastroesophageal reflux disease: a meta-analysis.
Shifeng FuMengmeng XuHejun ZhouYongjun WangYuyong TanDengliang LiuPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2021)
A total of 103,048 patients from 15 studies were included. The combined results suggest that MetS is a risk factor of GERD (OR: 1.66, 95%CI: 1.38-1.99). Among the individual metabolic components, abdominal obesity (OR: 1.42, 95%CI: 1.22-1.64), hypertriglyceridemia (OR: 1.50, 95%CI: 1.27-1.78), hyperglycemia (OR: 1.31, 95%CI: 1.07-1.61), and hypertension (OR: 1.19, 95%CI: 1.07-1.33) are risk factors of GERD. Conclusions and Inferences. MetS is a risk factor of GERD, and among the abnormal metabolic components that establish the diagnosis of MetS, abdominal obesity, hypertriglyceridemia, hyperglycemia, and hypertension are risk factors of GERD.
Keyphrases
- risk factors
- gastroesophageal reflux disease
- metabolic syndrome
- insulin resistance
- blood pressure
- weight loss
- end stage renal disease
- ejection fraction
- type diabetes
- newly diagnosed
- weight gain
- prognostic factors
- high fat diet induced
- uric acid
- body mass index
- oxidative stress
- physical activity
- patient reported outcomes