Negative prognostic impact of epidermal growth factor receptor copy number gain in young adults with isocitrate dehydrogenase wild-type glioblastoma.
Daniel I HoffmanKalil G AbdullahMakayla McCoskeyZev A BinderDonald M O'RourkeArati S DesaiMacLean P NasrallahAshkan BigdeliJennifer J D MorrissetteSteven BremStephen J BagleyPublished in: Journal of neuro-oncology (2019)
EGFR CN gain may be associated with inferior outcomes in young adults with newly diagnosed, IDH-WT GBM, suggesting a potential role for targeting EGFR in this population.
Keyphrases
- epidermal growth factor receptor
- wild type
- copy number
- newly diagnosed
- mitochondrial dna
- young adults
- tyrosine kinase
- advanced non small cell lung cancer
- genome wide
- dna methylation
- lymph node metastasis
- cancer therapy
- small cell lung cancer
- squamous cell carcinoma
- gene expression
- childhood cancer
- insulin resistance
- skeletal muscle
- glycemic control
- low grade