Sam50 exerts neuroprotection by maintaining the mitochondrial structure during experimental cerebral ischemia/reperfusion injury in rats.

Xulong YinJiahe WangSiyuan YangHaiying LiHai-Tao ShenHui WangXiang Li Heng Gao

Published in: CNS neuroscience & therapeutics (2022)

Sam50 played a vital role in the protection of neurons and mitochondria in cerebral I/R injury, which could be a novel target for mitochondrial protection and ameliorating I/R injury.

Keyphrases

subarachnoid hemorrhage
cerebral ischemia
oxidative stress
brain injury
spinal cord
cell death
cerebral blood flow
blood brain barrier
endoplasmic reticulum