Preparation and optimization of silibinin-loaded chitosan-fucoidan hydrogel: an in vivo evaluation of skin protection against UVB.

Masood Ali KaramiBehzad Sharif Makhmal ZadehMahsa PooranianAnnahita Rezaie

Published in: Pharmaceutical development and technology (2020)

Optimized hydrogel effectively reduced the inflammation mediators interleukin-22 and TNF-α, which signify tissue destruction. Therefore, silibinin-loaded hydrogel can be introduced as an effective sun-protective product.

Keyphrases

wound healing
drug delivery
cancer therapy
hyaluronic acid
oxidative stress
rheumatoid arthritis
mass spectrometry
molecularly imprinted
high resolution