Comparative analysis of somatic variant calling on matched FF and FFPE WGS samples.

Louise de Schaetzen van BrienenMaarten LarmuseauKim Van der EeckenFrederic De RyckPauline RobbeAnna SchuhJan FostierPiet OstKathleen Marchal

Published in: BMC medical genomics (2020)

This study illustrates that when using the correct variant calling strategy, the majority of clonal SNVs can be recovered in an FFPE sample with high precision and sensitivity. These results suggest that somatic variants derived from WGS of FFPE material can be used in cohort studies.

Keyphrases

copy number
gene expression