Precision Cardiology: Phenotype-targeted Therapies for HFmrEF and HFpEF.
Giuseppe M C RosanoCristiana VitaleIlaria SpoletiniPublished in: International journal of heart failure (2024)
Heart failure with mid-range ejection fraction (HFmrEF) and preserved ejection fraction (HFpEF) represent over half of heart failure cases but lack proven effective therapies beyond sodium-glucose cotransporter 2 inhibitor and diuretics. HFmrEF and HFpEF are heterogeneous conditions requiring precision phenotyping to enable tailored therapies. This review covers concepts on precision medicine approaches for HFmrEF and HFpEF. Areas discussed include HFmrEF mechanisms, anti-inflammatory and antifibrotic treatments for obesity-related HFpEF, If inhibition for HFpEF with atrial fibrillation, and mineralocorticoid receptor antagonism for chronic kidney disease-HFpEF. Incorporating precision phenotyping and matched interventions in HFmrEF and HFpEF trials will further advance therapy compared to blanket approaches.
Keyphrases
- ejection fraction
- heart failure
- aortic stenosis
- atrial fibrillation
- chronic kidney disease
- anti inflammatory
- type diabetes
- high throughput
- metabolic syndrome
- insulin resistance
- stem cells
- acute kidney injury
- weight gain
- transcatheter aortic valve replacement
- aortic valve
- acute coronary syndrome
- bone marrow
- percutaneous coronary intervention
- mitral valve
- high fat diet induced