Layered terbium hydroxides for simultaneous drug delivery and imaging.
Margarita StrimaiteClarissa L G HarmanHuan DuanYuwei WangGemma-Louise DaviesGareth R WilliamPublished in: Dalton transactions (Cambridge, England : 2003) (2022)
Layered rare-earth hydroxides have begun to gather increasing attention as potential theranostic platforms owing to their extensive intercalation chemistry combined with magnetic and fluorescent properties. In this work, the potential of layered terbium hydroxide (LTbH) as a platform for simultaneous drug delivery and fluorescence imaging was evaluated. LTbH-Cl ([Tb2(OH)5]Cl·yH2O) was loaded with three nonsteroidal anti-inflammatory drugs (diclofenac, ibuprofen, and naproxen) via ion-exchange. Drug release studies in phosphate buffered saline (pH = 7.4) revealed all three formulations release their drug cargo rapidly over the course of approximately 5 hours. In addition, solid state fluorescence studies indicated that fluorescence intensity is strongly dependent on the identity of the guest anion. It was postulated that this feature may be used to track the extent of drug release from the formulation, which was subsequently successfully demonstrated for the ibuprofen loaded LTbH. Overall, LTbH exhibits good biocompatibility, high drug loading, and a strong, guest-dependent fluorescence signal, all of which are desirable qualities for theranostic applications.
Keyphrases
- drug delivery
- fluorescence imaging
- drug release
- cancer therapy
- photodynamic therapy
- solid state
- single molecule
- reduced graphene oxide
- anti inflammatory drugs
- energy transfer
- highly efficient
- high resolution
- working memory
- human health
- quantum dots
- transition metal
- adverse drug
- risk assessment
- drug induced
- high throughput
- case control
- climate change
- living cells
- ionic liquid
- high intensity
- iron oxide
- drug discovery
- neural network