Factors affecting the electrocardiographic QT interval in malaria: A systematic review and meta-analysis of individual patient data.
Xin Hui S ChanYan Naung WinIlsa Louisa HaeuslerJireh Y TanShanghavie LoganathanSompob SaralambaShu Kiat S ChanElizabeth A AshleyKaren I BarnesRita BaidenPeter U BassiAbdoulaye A DjimdeGrant DorseyStephan DuparcBorimas HanboonkunupakarnFeiko O Ter KuileMarcus V G LacerdaAmit NasaFrancois H NostenCyprian O OnyejiSasithon PukrittayakameeAndré Machado de SiqueiraJoel TarningWalter R J TaylorGiovanni ValentiniMichèle van VugtDavid WescheNicholas Philip John DayChristopher L-H HuangJosep BrugadaRichard N PriceNicholas J WhitePublished in: PLoS medicine (2020)
Adjustment for malaria and fever-recovery-related QT lengthening is necessary to avoid misattributing malaria-disease-related QT changes to antimalarial drug effects. This would improve risk assessments of antimalarial-related cardiotoxicity in clinical research and practice. Similar adjustments may be indicated for other febrile illnesses for which QT-interval-prolonging medications are important therapeutic options.