Hypofibrinolytic state and high thrombin generation may play a major role in SARS-COV2 associated thrombosis.

Christophe NougierRemi BenoitMarie SimonHelene Desmurs-ClavelGuillaume MarcotteLaurent ArgaudJean Stephane DavidAurelie BonnetClaude NegrierDargaud Yesim

Published in: Journal of thrombosis and haemostasis : JTH (2020)

We observed two key findings: a high thrombin generation capacity that remained within normal values despite heparin therapy and a hypofibrinolysis mainly associated with increased PAI-1 levels. A modified ROTEM is able to detect both hypercoagulability and hypofibrinolysis simultaneously in Covid-19 patients with thrombosis.

Keyphrases

sars cov
pulmonary embolism
coronavirus disease
respiratory syndrome coronavirus
venous thromboembolism
stem cells
bone marrow
growth factor