Generation of non-genetically modified, CAR-like, NK cells.

Loïs CoënonEmilie RigalHortense Courot Caroline MultrierSara ZemitiJennifer LambourMartine Pugnière Marion de Toledo Guillaume Bossis Guillaume Cartron Bruno Robert Pierre Martineau Bénédicte Fauvel Jessy Presumey Martín Villalba

Published in: Journal for immunotherapy of cancer (2024)

The Pin technology provides an off-the-shelf NK cell therapy platform to generate CAR-like NK cells, without genetic modifications, that easily target multiple tumor antigens.

Keyphrases

nk cells
cell therapy
stem cells
mesenchymal stem cells
genome wide
high throughput
dendritic cells
copy number
dna methylation