Discovery of highly insecticidal synthetic spinosyn mimics - CAMD enabled de novo design simplifying a complex natural product.

Thomas C SparksGary D CrouseDavid A DemeterGeno SamaritoniCasandra L McLeod

Published in: Pest management science (2018)

Simplifying complex natural products: Computer modeling-based design leads to highly insecticidal, chemically simpler synthetic mimics of the spinosyn natural products that are active in the field. © 2018 Society of Chemical Industry.

Keyphrases

small molecule
deep learning
high throughput
machine learning
single cell