Packaging of supplemented urokinase into naked alpha-granules of in vitro -grown megakaryocytes for targeted therapeutic delivery.

Mortimer PonczSergei V ZaitsevHyunsook AhnM Anna KowalskaKhalil BdeirRodney M CamireDouglas B CinesVictoria Stepanova

Published in: bioRxiv : the preprint server for biology (2023)

Unlike platelets, in vitro-grown megakaryocytes can store exogenous uPA in its α-granules.uPA uptake involves LRP1 and αIIbβ3 receptors and is functionally available from activated platelets.

Keyphrases

plant growth
cancer therapy
red blood cell