PDXGEM: patient-derived tumor xenograft-based gene expression model for predicting clinical response to anticancer therapy in cancer patients.

Youngchul KimDaewon KimBiwei CaoRodrigo CarvajalMinjung Kim

Published in: BMC bioinformatics (2020)

Our results demonstrated the strong potential of using molecular profiles and drug activity data of PDX tumors in developing a clinically translatable predictive cancer biomarkers for cancer patients. The PDXGEM web application is publicly available at http://pdxgem.moffitt.org .

Keyphrases

gene expression
papillary thyroid
dna methylation
squamous cell
electronic health record
big data
emergency department
single molecule
adverse drug
squamous cell carcinoma
childhood cancer
human health
stem cells
drug induced
mesenchymal stem cells
bone marrow
risk assessment
cell therapy
artificial intelligence